Electric Literature of 622-75-3, A common heterocyclic compound, 622-75-3, name is 2,2′-(1,4-Phenylene)diacetonitrile, molecular formula is C10H8N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Ag(CF3SO3) (0.0231g, 0.090mmol) and p-phda (0.0281g, 0.180mmol) were dissolved in 10mL benzene. After stirring for 30min, the resultant solution were transformed to a Teflon-lined stainless steel vessel (25mL) and heated at 120C for 2h, and then cooled to room temperature naturally. The resulting colorless crystals of 2 were isolated by slow evaporation the solution in air. Yield: 69.80% (based on Ag). Anal. Calc. for C21H16AgF3N4O3S C, 44.30; N, 9.84; H, 2.83; Found: C, 44.03; N, 9.74; H, 2.70%. IR:(KBr, nu/cm-1): 2960(w), 2918(w), 2258(w), 1521(m), 1427(m), 1410(m), 1288(s), 1255(s), 1224(m), 1174(s), 1031(s), 933(m), 785(m), 761(m), 629(s), 519(m).
The synthetic route of 622-75-3 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Han, Jing; Yang, Jian; Yu, Zhong; Wang, Quan-jiu; Inorganica Chimica Acta; vol. 469; (2018); p. 318 – 324;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts