Reference of 16532-79-9, The chemical industry reduces the impact on the environment during synthesis 16532-79-9, name is 4-Bromophenylacetonitrile, I believe this compound will play a more active role in future production and life.
General procedure: Sodium methoxide (4 mmol) – methanol solution was slowly added to a solution of 4 (1.0 g, 2.12 mmol) and I2 (0.51 g, 2.01 mmol) in dry diethyl ether at -78C. The reaction mixture was stirred for 12 h at rt. The crude product was filtered and washed with water and methanol. The residue was purified by silica gel column chromatography. The pure 1 was obtained by size-exculsion chromatography (JAIGEL-2H and 1H, CHCl3). Title compound was obtained as an orange solid (200 mg, 20%).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromophenylacetonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Furuyama, Taniyuki; Shinozaki, Junichi; Tasso, Thiago Teixeira; Maeda, Hajime; Segi, Masahito; Kobayashi, Nagao; Tetrahedron Letters; vol. 58; 45; (2017); p. 4243 – 4247;,
Nitrile – Wikipedia,
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