Electric Literature of 6011-14-9, The chemical industry reduces the impact on the environment during synthesis 6011-14-9, name is 2-Aminoacetonitrile hydrochloride, I believe this compound will play a more active role in future production and life.
Compound 9f (45 mg, 0.157 mmol)And N, N-dimethylformamide (5mL) into a three-necked flask,Then 9g of compound (16.78mg, 0.181mmol) was added in order while stirring,N, N-diisopropylethylamine (70.2 mg, 0.544 mmol) and2- (7-benzotriazole) -N, N, N ‘, N’-TetramethylureaHexafluorophosphate(68.9mg, 0.181mmol),Stir overnight at room temperature,The reaction solution was poured into ice water (20 mL),Then filtered and dried,Compound 9 was obtained as a yellow solidN- (cyanomethyl) -1 (2 (-(1-methyl-1H-pyrazol-4-yl) amino) pyrimidin-4-yl) -1H-pyrazole-4-carboxamide(30.3 mg, yield 59.4%).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Aminoacetonitrile hydrochloride, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Jiaxing Tekeluo Biological Technology Co., Ltd.; Xing Li; Li Guanqun; Wang Xiaolei; Cai Yuting; Jiang Xiang; Pan Xiang; Zhu Wenhao; Wang Yang; Wang Zengquan; (44 pag.)CN110734428; (2020); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts