Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 455-18-5, name is 4-(Trifluoromethyl)benzonitrile, A new synthetic method of this compound is introduced below., Quality Control of 4-(Trifluoromethyl)benzonitrile
1, 4-addition of 50% hydroxylamine aqueous solution (11.6g) in (trifluoromethyl) benzonitrile (10g) solution of ethanol (100), and stirred overnight at 80 C. After the reaction, the solvent was removed by distillation, and water was added. After collecting the insoluble matter was filtered dried to give the N- hydroxy-4- (trifluoromethyl) benzamidine (12.6g). MS (ESI) m / z: 205 (M + H) +.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Mitsubishi Tanabe Pharma Corporation; Watanabe, Masayuki; Furukawa, Hiroyuki; Hamada, Maiko; Fuji, Naoto; Ushio, Hiroyuki; Takashima, Toru; (81 pag.)KR2015/2661; (2015); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts