Electric Literature of 199536-01-1, A common heterocyclic compound, 199536-01-1, name is Methyl 3-amino-5-cyanobenzoate, molecular formula is C9H8N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
CH3SO2Cl (40 mmol) was added to the solution of methyl-3-amine-5-cyanobenoate (10 mmol), pryridine (50 mmol) and DMAP (1 mmol) in DCM (150 mL). The solution was then heated to reflux for 4 hours. After cooling, diluted hydrochloric acid was poured into the solution. The organic layer was washed with water and brine sequentially, dried over anhydrous Na2SO4, and concentrated. The crude product was purified by column chromatography to afford methyl-3-cyano-5-(methylsulfonamido)benoate in 70% yield.
The synthetic route of 199536-01-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Hutchison Medipharma Enterprises Limited; US2009/118292; (2009); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts