Electric Literature of 64248-62-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 64248-62-0, name is 3,4-Difluorobenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
To a solution of terf-butyl-(S)-3-hydroxypyrrolidine-l-carboxylate (4.44 g, 23.7 mmol) in N,N- dimethylformamide (40 mL), sodium hydride (1.72 g, 43.1 mmol) was added under nitrogen atmosphere at 0 C and stirred for 30 min. To the resulting reaction mixture, 3,4-difluorobenzonitrile (3 g, 21.6 mmol) in /V, /V-di methylformam ide (10 mL) was added slowly at 0 C and stirred at 25 C for 2 h. The reaction mixture was quenched with ammonium chloride solution and diluted with ethyl acetate (100 mL). The dichloromethane layer was collected and washed twice with water (80 mL), dried over anhydrous sodium sulphate and concentrated under reduced pressure to obtain the crude product. The crude product was purified by flash column chromatography on silica gel by eluent 50% ethyl acetate in hexane to obtain tert- butyl (S)-3-(4-cyano-2-fluorophenoxy)pyrrolidine-l-carboxylate (5.3 g, 17.3 mmol, 80% yield).
The synthetic route of 3,4-Difluorobenzonitrile has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PI INDUSTRIES LTD.; BHUJADE, Paras Raybhan; NAIK, Maruti N; PAWAR, Rajesh; TRIVEDI, Pooja; DENGALE, Rohit Arvind; KULKARNI, Shantanu Ganesh; TEMBHARE, Nitin Ramesh; AUTKAR, Santosh Shridhar; GARG, Ruchi; VENKATESHA, Hagalavadi M; KLAUSENER, Alexander G.M.; (172 pag.)WO2020/70610; (2020); A1;,
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