Adding a certain compound to certain chemical reactions, such as: 330793-38-9, name is 4-Bromo-2-methoxybenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 330793-38-9, Formula: C8H6BrNO
Preparation 17: 2-methoxy-4-(4,4,5,5-tetramethyl-1 ,3,2-dioxaborolan-2- yl)benzamide; Step 1 : 4-bromo-2-methoxybenzamide; To a solution of 4-bromo-2-methoxybenzonitrile (Preparation 16, Step 1 , 2.0Og, 9,43 mmol) in ethanol (6 ml_) was added 10percent aqueous potassium hydroxide (5.30 ml_, 943 mmol). The reaction was heated to 8O0C for 16 h. An additional amount of 10percent aqueous potassium hydroxide (5.3OmL) was added to the reaction and the mixture was stirred for 8 h at 8O0C. The reaction was cooled to room temperature and a solid precipitated. The mixture was filtered to yield the title compound as a white solid 4 (658 mg, 30percent). 1H NMR (500 MHz, DMSO-Cf6) delta ppm 7.70 (d, 1 H), 7.60 (bs, 2H), 7.54 (s, 1 H), 7.22 (d, 1H), 3.90 (s, 3H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-2-methoxybenzonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; PFIZER INC.; ARHANCET, Graciela Barbieri; CASIMIRO-GARCIA, Agustin; CHEN, Xiangyang; HEPWORTH, David; MEYERS, Marvin Jay; PIOTROWSKI, David Walter; RAHEJA, Raj Kumar; WO2010/116282; (2010); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts