Some common heterocyclic compound, 3759-28-2, name is 2-(Cyanomethyl)benzonitrile, molecular formula is C9H6N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 2-(Cyanomethyl)benzonitrile
General procedure: A mixture of 2-oxo-6-aryl-4-piperidin-1-yl-2H-pyran-3-carbonitrile (1.0 mmol), 2-cyanomethylbenzonitrile (1.0mmol, 142.0 mg), and NaNH2 (2.0 mmol, 78.0 mg) in dryDMF (2.0 mL) was heated at 100 C for 55 min undermicrowave irradiation. Completion of reaction wasmonitored by TLC. After completion, the reaction mixturewas poured onto crushed ice and neutralized with 10% HCl.The precipitate obtained was filtered, washed with H2O,dried, and purified by silica gel column chromatographyusing hexane-EtOAc (7:3) as eluent.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3759-28-2, its application will become more common.
Reference:
Article; Singh, Surjeet; Yadav, Pratik; Sahu, Satya Narayan; Sharone, Ashoke; Kumar, Brijesh; Ram, Vishnu Ji; Pratap, Ramendra; Synlett; vol. 25; 18; (2014); p. 2599 – 2604;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts