Reference of 21803-75-8, A common heterocyclic compound, 21803-75-8, name is 4-Amino-3-chlorobenzonitrile, molecular formula is C7H5ClN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
An ethanolic solution (5 mL) of 4-amino-3-chlorobenzonitrile (L2, 1 mmol, 0.153 g) was added tothe saturated ethanolic solution (5 mL) of AgNO3. The test tube was covered with a perforated foil.After keeping the solution in air for 6 days, light yellow crystals of 2 suitable for structure determinationwere obtained. Yield 72%, m.p. 152-153 C. Anal. Calcd for C7H5AgClN3O3: C, 26.07; H, 1.56;N, 13.03%. Found: C, 26.04; H, 1.58; N, 13.01%. IR (KBr, cm-1): 3481 (m), 3361 (s), 3184 (w), 2360 (m),2206 (s), 1755 (w), 1645 (s), 1590 (m), 1525 (m), 1381 (s), 1206 (w), 887 (w), 810 (w), 666 (w), 578(w). 1H NMR (400 MHz, DMSO) delta/ppm: 7.69 (d, J = 1.9 Hz, 1H), 7.42 (dd, J = 8.5, 1.9 Hz, 1H), 6.82(d, J = 8.5 Hz, 1H), 6.42 (s, 2H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Qian, Wei; Yuan, Hao-Kun; Zhang, Ran; Fang, Rui-Qin; Journal of Coordination Chemistry; vol. 69; 23; (2016); p. 3593 – 3602;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts