Synthetic Route of 60702-69-4,Some common heterocyclic compound, 60702-69-4, name is 2-Chloro-4-fluorobenzonitrile, molecular formula is C7H3ClFN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a 100L reaction vessel were added ethanol (40L) and 2-chloro-4-fluorobenzonitrile (7kg). Then hydrazine hydrate (4 L) was added. The resulting mixture was heated to reflux for 5 hours, then cooled, and subjected to centrifugal filtration. The resulting solid was introduced into a 100L reaction vessel. Anhydrous ethanol (40L) was added, and then concentrated hydrochloric acid (7.5L) was slowly added. The resulting mixture was heated to reflux for 2 hours, subjected to centrifugal filtration, and dried to produce 2-chloro-4-hydrazinobenzonitrile hydrochloride (7kg), yield: 76.2%.
The synthetic route of 60702-69-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; KBP Biosciences Co., Ltd.; JIANG, Chen; WANG, Aichen; ZHANG, Dedong; EP2937348; (2015); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts