Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 52798-01-3, name is Methyl (4-cyanophenyl)acetate, A new synthetic method of this compound is introduced below., Product Details of 52798-01-3
Step S2:Compound 2 (212 g) was added to the reactor under nitrogen, and THF (3 L) and PMHS (269 g) were added and cooled to 0 C;NaBEt3H (120.7 g) was added dropwise with stirring at 0 to 10 C, warmed to room temperature and stirred for 20 hours (the product of this stage was analyzed by IPC).Cool to 0 ~ 10 C, slowly add 500 ml of methanol at 0 C, add 2 L of saturated NaCl aqueous solution,Stir for 15 minutes, separate, and the aqueous phase was extracted with 1L ethyl acetate.The combined organic layers were dried over Na2SO4, concentrated, and then applied107 g of Compound 3 (IPC retention time: 1.61 min) was obtained as a yellow solid.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Huidingzhiyao (Beijing) Technology Co., Ltd.; Wang Zaiqi; Yang Lihu; (20 pag.)CN108864114; (2018); A;,
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