Adding a certain compound to certain chemical reactions, such as: 218632-01-0, name is 3-Fluoro-4-nitrobenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 218632-01-0, name: 3-Fluoro-4-nitrobenzonitrile
Synthesis of 3-((3,4-dimethylphenyl)amino)-4-nitrobenzonitrile To 3,4-dimethylaniline (4.4 g, 35.9 mmol) in THF (100 mL) was added sodium hydride (95% in mineral oil, 1.34 g, 55.8 mmol) and stirred for 1 hour. 3-Fluoro-4-nitrobenzonitrile (5.0 g, 30.1 mmol) was added and the reaction mixture was heated to reflux for 8 hours. Reaction mixture was cooled to room temperature, water was added and filtered through silica gel, washed with 5% THF in hexane and concentrated in vacuo. The crude mixture was purified by flash column chromatography with 5-10% THF in hexane to give 3-((3,4-dimethylphenyl)amino)-4-nitrobenzonitrile (3.4 g, 36% yield) as an orange powder.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Fluoro-4-nitrobenzonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Universal Display Corporation; KWONG, Raymond; LAM, Sze Kui; LAM, Siu Tung; TSANG, Kit Yee; LEE, Chi Hang; SZIGETHY, Geza; (159 pag.)US2016/218303; (2016); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts