Application of 77668-42-9, A common heterocyclic compound, 77668-42-9, name is 2,3-Dichlorobenzoyl cyanide, molecular formula is C8H3Cl2NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
400 g (2 moles) of 2,3-dichlorobenzoyl cyanide are added to a mixture prepared from 333.6 g (2.45 moles) of aminoguanidine bicarbonate in 800 mL of methanesulphonic acid. The mixture is then heated at 45C for 5 hours, cooled to 10C and 2.4 L of water is added slowly, controlling exothermy at 20-30C. The mixture is then adjusted to pH 11 with a 50% NAOH solution, filtered, the solid washed with water and dried at 45C to yield 419.8 g (82%) of the product of the title. NMR 1H (DMSO), delta (ppm): 6. 5- 6. 9 (s, 4H,-N=C (NH2) 2), 7.4 (t, 1H, ARH), 7. 6 (d, 2H, ArH). M. p. = 180-183C.
The synthetic route of 77668-42-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; LABORATORIOS VITA, S.A.; WO2004/39767; (2004); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts