Electric Literature of 628-20-6, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 628-20-6 as follows.
EXAMPLE 27 5-(3-CHLOROPROPYL)TETRAZOLE A mixture of 4-chlorobutyronitrile, (0.05 mol) sodium azide (0.20 mol) and anhydrous aluminum chloride (0.05 mol) in 100 ml of dry tetrahydrofuran is refluxed for 24 hours. After cooling to ambient temperature the reaction is acidified with 75 ml of 15% hydrochloric acid while the hydrazoic acid generated is removed by means of an aspirator. The organic and aqueous layers are then separated and the aqueous layer extracted with ethylacetate. The combined organic extracts are dried (magnesium sulfate) and evaporated to give 5-(3-chloropropyl)tetrazole which is used directly in the next step.
According to the analysis of related databases, 628-20-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Rhone-Poulenc Rorer Pharmaceuticals Inc.; US5166210; (1992); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts