Related Products of 24056-34-6, A common heterocyclic compound, 24056-34-6, name is 4-Hydroxycyclohexanecarbonitrile, molecular formula is C7H11NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a mixture of 4-hydroxycyclohexane-l-carbonitrile (1.5 g, 12 mmol) and pyridine (1.16mL, 14.4 mmol) in DCM (30 mL) was added triflic anhydride (2.7 mL, 14.4 mmol) at about -20 C. The solution was then kept at -5 to 0 C by an ice-salt bath. After lhr, the mixture was diluted with hexane (double the volume of DCM) and filtered through a pad of Celite. The solvent was evaporated to afford the crude triflates that were used directly for the coupling reaction
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; GENENTECH, INC.; NEWLINK GENETICS CORPORATION; PEI, Zhonghua; PARR, Brendan; LIU, Wendy; PASTOR, Richard; GAZZARD, Lewis; JAIPURI, Firoz; KUMAR, Sanjeev; POTTURI, Hima; WU, Guosheng; LIN, Xingyu; CHU, Yanyan; YUEN, Po-wai; (149 pag.)WO2019/6047; (2019); A1;,
Nitrile – Wikipedia,
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