Reference of 403-54-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 403-54-3 name is 3-Fluorobenzonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
A solution of 3-fluorobenzonitrile (1 g, 8.26 mmol) in ethanol (12 mL) was cooled to 0-5 C. HCl (gas) was bubbled through the mixture until saturation and the mixture was stirred at RT for 16 h. All volatiles were removed and to the residue was added diethyl ether (20 mL). The obtained suspension was filtered, washed with diethyl ether and dried in vacuo to give the product as colorless solid (1.57 g, 7.71 mmol, 93.4% yield). MS: M=168.2 (M-HCl+H)+
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Fluorobenzonitrile, and friends who are interested can also refer to it.
Reference:
Patent; Bachmann, Stephan; Flohr, Alexander; Zbinden, Katrin Groebke; Koerner, Matthias; Kuhn, Bernd; Peters, Jens-Uwe; Rudolph, Markus; US2013/59833; (2013); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts