Electric Literature of 21803-75-8, These common heterocyclic compound, 21803-75-8, name is 4-Amino-3-chlorobenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To 4-amino-3-chlorobenzonitrile (52 mg, 0.34 mmol), Cs 2CO 3 (130 mg, 0.4 mmol) were added to tert-butyl 5-chloro-3-formyl-6-methylpyrazolo[1,5-a]pyrimidin-7-yl(cyclopropyl)carbamate (100 mg, 0.29 mmol) dissolved in 1,4-dioxane (1.1 mL). Racemic BINAP (11 mg, 0.017 mmol) and palladium(II) acetate (8 mg, 0.011 mmol) were then added. The mixture was sealed and irradiated at 110 C. for 60 min in the microwave. Et 2O (3 mL) was added and the solution was filtered. The filtrate was concentrated in vacuo.
The synthetic route of 21803-75-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SENHWA BIOSCIENCES INCORPORATED; HADDACH, MUSTAPHA; TRAN, JOE A; PIERRE, FABRICE; REGAN, COLLIN F; RAFFAELE, NICHOLAS B; RAVULA, SUCHITRA; RYCKMAN, DAVID M; (482 pag.)JP5802676; (2015); B2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts