Related Products of 330793-38-9,Some common heterocyclic compound, 330793-38-9, name is 4-Bromo-2-methoxybenzonitrile, molecular formula is C8H6BrNO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: Following general procedure Q, 4-bromo-2-methoxybenzonitrile (108 mg, 0.51 mmol) gave (4-bromo- 2-methoxy-phenyl)methanamine (67.2 mg, 0.31 mmol, 61 percent yield). NMR (500 MHz, CDCI3, delta): 7.12-7.02 (m, 2H), 7.00-6.96 (m, 1 H), 3.84 (s, 3H), 3.77 (s, 2H). To a solution of cobalt (II) chloride (1 eq.) and nitrile derivative (1 eq.) in anhydrous MeOH (0.05 M), cooled to 0 ¡ãC under a nitrogen atmosphere, was added sodium borohydride (10 eq) portion wise over 10 min. The reaction mixture was then stirred for 20 min at 0 ¡ãC and then stirred for a further 60 min at room temperature, quenched with an aqueous solution of ammonium chloride, and allowed to stand overnight. Most of methanol was removed under reduced pressure and the remaining aqueous mixture was diluted with water and washed with Epsilon2theta (x 2). The aqueous layer was basified to pH = 12 with 1 M NaOH and extracted with CHC (* 3). The combined organics were dried (phase separator) and concentrated to give the desired amine.
The synthetic route of 330793-38-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; REDX PHARMA PLC; GUISOT, Nicolas; (191 pag.)WO2017/46604; (2017); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts