Reference of 1735-53-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1735-53-1, name is 4-Bromo-3-(trifluoromethyl)benzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
A mixture of [4-BROMO-3- (TRIFLUOROMETHYL)-BENZONITRILE] (Yonezawa [ET AG,] Synthetic Communications (1996) 26,1575-8 ; 2.47 g, 12 [MMOL),] 1-methylpiperazine (Fluka, Buchs, Switzerland, 5.33 mL, 48 [MMOL)] and 15 mL [N, N-DIMETHYLACETAMIDE] is stirred in a tightly closed vessel for 14 hours at [95C.] After cooling, the reaction mixture is evaporated to dryness under reduced pressure and the residue is treated with a half-saturated aqueous solution of sodium carbonate and extracted with ethyl acetate. The combined extracts are dried [(NA2SO4)] and the solvent is evaporated off under reduced pressure. The crude product is purified by column chromatography on silica gel, eluent methylene chloride/methanol to give [4- (4-METHYL-1-PIPERAZINYL)-3- (TRIFLUOROMETHYL)-BENZONITRILE] as a pale yellow oil. A mixture consisting of 30 mL dioxane, 15 mL water and 11.25 mL of 2M aqueous sodium hydroxide solution is added to [4- (4-METHYL-1-PIPERAZINYL)-3- (TRIFLUOROMETHYL)-BENZONITRILE] and the reaction mixture is shaken for 16 hours at [95C.] After cooling, the mixture is evaporated. The resulting residue is treated with water, the pH adjusted [TO-5-6] with 1 M hydrochloric acid and the solvent evaporated off under reduced pressure. The residue is treated with hot methanol, the insoluble salt filtered off and the filtrate evaporated yielding the crude title compound which is used for the next step without further purification. [‘H-NMR] (400 MHz, [DMSO-D6,] [8)] : 2.28 (s, 3H); 2.50-2. 58 (m, 4H); 2.94-3. 02 (m, 4H); 7.52 [(M, 1 H) ; 8.11-8. 17 (M, 2H); 13.19 (BR. , 1 H).]
The synthetic route of 4-Bromo-3-(trifluoromethyl)benzonitrile has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; WO2004/29038; (2004); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts