Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 64248-62-0, name is 3,4-Difluorobenzonitrile, A new synthetic method of this compound is introduced below., Application In Synthesis of 3,4-Difluorobenzonitrile
In N, N-dimethylformamide (DMF, 40 mL)(R) -2- (4-hydroxyphenoxy) propionic acid (3.03 g, 0.02 mol) was added,Potassium carbonate (5.52 g, 0.04 mol) was added in portions,Heating to 70 C to 80 C,Continuous stirring 1h,(2.38 g, 0.02 mol) of 3,4-difluorobenzonitrile was added in portions,Continue to stir the reaction 6 ~ 7h.Cooled to room temperature,Poured into ice water (250 mL)Slowly add dilute hydrochloric acid,Adjusted to pH 4 to 5,Filter,Washed,(R) -2- [4- (4-cyano-2-fluorophenoxy) phenoxy] propionic acid as a gray solid in (R) -2- [4- (4-cyanide) Yl-2-fluorophenoxy) phenoxy] propionic acid3.26g,Yield 65.7%.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; China Three Gorges University; Liu, Qixing; Zhou, Haifeng; Zhu, Rui; Chen, Lei; (9 pag.)CN106632007; (2017); A;,
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