Application of 622-75-3, A common heterocyclic compound, 622-75-3, name is 2,2′-(1,4-Phenylene)diacetonitrile, molecular formula is C10H8N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Scheme I, step A: Into a 250 ML single neck flask was placed sodium hydride 60% (5.4 g, 134.5 mmol) in DMF (100 ML) at -15 C. 1,4-Phenyldiacetonitrile (5 g, 32 mmol) was added to the solution slowly and the mixture was stirred for 1/2 hour.The reaction mixture was treated with methyl iodide (8.4 ML, 134.5 mmol).The mixture was warmed up to RT while stirring for 12 hours.The reaction mixture was poured into ice water (600 ML) until product was precipitated out.The precipitate was filtered off and washed with cold water to provide the intermediate title compound, 2-[4-(1-cyano-isopropyl)phenyl]-2-methylpropanenitrile, (6.8 g, 100%) as a white solid.Electron spray M.S. 230 (M*+H2O).
The synthetic route of 622-75-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Knobelsdorf, James Allen; Shepherd, Timothy Alan; Tromiczak, Eric George; Zarrinmayeh, Hamideh; Zimmerman, Dennis Michael; US2003/229102; (2003); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts