Adding a certain compound to certain chemical reactions, such as: 26391-06-0, name is 2-Cyano-N,N-diethylacetamide, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 26391-06-0, HPLC of Formula: C7H12N2O
To a solution of N,N-diethylcyanoacetamide (14.1 g, 0.1 mol) in toluene (100 mL) was added IRA 96 resin (0.2 g) and 2-methoxy-5-nitrobenzaldehyde (18.1 g, 0.1 mol). Then the mixture was heated to reflux, released water being collected azeotropically, until TLC test showed the absence of starting materials. The reaction mixture was filtered hot. The filtrate was evaporated completely and the residue was purified with ethanol to afford 1o. (2.2 g, 73 %) as a white solid; mp 134-135 C (EtOH); numax (liquid film) 3074, 2934, 2212, 1633, 1518, 1342 cm-1; deltaH (400 MHz, CDCl3) 1.2 (6H, br s (CH3)3), 3.5 (4H, br s, (CH2)2), 4.0 (3H, s, OMe), 7.0 (1ArH, d, J 9.2 Hz), 7.94 (1H, s, vinyl), 8.3 (1ArH, dd, J 9.2, 2.3 Hz), 9.0 (1ArH, d, J 2.4 Hz); m/z 303.2 (MH+).
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Reference:
Article; Harisha, Attimogae Shivamurthy; Nayak, Suresh Parameshwar; Nagarajan, Kuppuswamy; Row, Tayur Narasingarow Guru; Hosamani, Amar A.; Tetrahedron; vol. 72; 22; (2016); p. 2880 – 2889;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts