Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 268734-34-5, name is Methyl 4-cyano-3-fluorobenzoate, A new synthetic method of this compound is introduced below., HPLC of Formula: C9H6FNO2
Step 13-1 : Synthesis of methyl 4-cyano-3 -(I H-pyrazol-l-yl)benzoate.[0271] Methyl 4-cyano-3-fluorobenzoate (0.30 g) and lH-pyrazole (0.14 g) were dissolved in N,N-dimethylformamide (10 ml). To the reaction solution, sodium hydride (0.10 g) was added under ice cooling while stirring the mixture, and the mixture was stirred for 30 min. After increasing the temperature to room temperature, the solution was further stirred for 2 hours. The reaction solution was diluted with water and extracted twice with ethyl acetate. The organic phases were combined, washed with water, and then dried over anhydrous sodium sulfate. The drying agent was removed by filtration, and the solvent was distilled off under reduced pressure to obtain a crude product, which was then purified by column chromatography to give methyl 4-cyano-3-(lH-pyrazol-l-yl)benzoate (0.28 g, yield[0272] 1H-NMR (CDCl3) delta:3.99 (3H, s), 6.58 (IH, dd), 7.85-7.88 (2H, m), 8.06 (IH, dd), 8.18 (IH, dd), 8.43 (IH, d).
The synthetic route of 268734-34-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BAYER CROPSCIENCE AG; MIHARA, Jun; ARAKI , Koichi; MORI , Takuma; MURATA , Tetsuya; YONETA, Yasushi; WATANABE , Yukiyoshi; SHIMOJO , Eiichi; ICHIHARA , Teruyuki; ATAKA , Masashi; SHIBUYA , Katsuhiko; GOeRGENS, Ulrich; WO2011/18170; (2011); A2;,
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