These common heterocyclic compound, 1250444-23-5, name is 3-Bromo-2,6-difluorobenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 1250444-23-5
3-bromo-2,6-difluorobenzonitrile and triethyl phosphite in a 1: 8.0 proportion feeding, N2 Protection, reaction temperature 100 , reaction was carried out under the lighting conditions. TLC monitored the reaction to the raw material 30h point disappears. The product was distilled under reduced pressure, the oil bath temperature to 100 deg.] C, the low boiling fraction was distilled off. Again the product distilled under reduced pressure, the oil bath temperature to 190C, distilled high boiling fraction, taken when the steam temperature 135-145C fraction, the evaporated fraction dissolved in ethyl acetate, respectively, with 10% Na2CO3, Washed with saturated sodium chloride, dried over anhydrous magnesium sulfate, filtered and rotary evaporated to give a yellow oily liquid product, in 83% yield.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1250444-23-5.
Reference:
Patent; Tianjin Normal University; SONG, FANBO; ZHANG, ZHONGBIAO; LI, HUAYUN; TANG, HONGYING; WANG, ZHIQIANG; SONG, AIRU; (11 pag.)CN104004016; (2016); B;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts