Electric Literature of 939-79-7, A common heterocyclic compound, 939-79-7, name is 4-Methyl-3-nitrobenzonitrile, molecular formula is C8H6N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture of 0.32 g of 3-nitro-4-methyl-benzonitrile (1; 0.32 g, 2.0 mmol), 3-fluoro-4-bromo-benzaldehyde (35; 0.40 g, 2.0mmol), piperidine (0.1 mL, 1.0 mmol) and sulfolane (3 g) was heated in a sealed tube at 150-160 C for 1 h. After cooling to room temperature, water (10 mL) was added. The resulting precipitate was filtered and dried under high vacuum to provide 0.64 g (94%) of product as yellow solid.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Nguyen, Son T.; Williams, John D.; Butler, Michelle M.; Ding, Xiaoyuan; Mills, Debra M.; Tashjian, Tommy F.; Panchal, Rekha G.; Weir, Susan K.; Moon, Chaeho; Kim, Hwa-Ok; Marsden, Jeremiah A.; Peet, Norton P.; Bowlin, Terry L.; Bioorganic and Medicinal Chemistry Letters; vol. 24; 15; (2014); p. 3366 – 3372;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts