Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 17626-40-3, name is 3,4-Diaminobenzonitrile, A new synthetic method of this compound is introduced below., Recommanded Product: 17626-40-3
General procedure: Diisopropylcarbodiimide 82 mul (66.9 mg, 0.53 mmol, 1.20 equiv) DIC was added to a solution of 4-chlorobenzoylpyruvic acid 100 mg (0.44 mmol, 1.00 equiv) 12b and 73.8 mg (0.53 mmol, 1.20 equiv) of HOBt [CAS: 123333-53-9, 97% wetted with ? 14 wt % H2O] in 3.0 ml of DMF (abs) under Ar. The reaction mixture was stirred for 5 min. Then o-phenylenediamine (1.00 mol equiv) from 11a-f was added and the mixture was stirred at rt under Ar for 72 h. The precipitated product mixture obtained after filtration (or centrifugation) was triturated by 3 ml of Et2O and crystallized from DMSO (if not otherwise stated) to yield the main solid regioisomer 16 or 17.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Dobia?, Juraj; Ondru?, Marek; Addova, Gabriela; Boha?, Andrej; Beilstein Journal of Organic Chemistry; vol. 13; (2017); p. 1350 – 1360;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts