2941-29-9, name is Cyclopentanone-2-carbonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 2941-29-9
To a solution of intermediate 15-e ( 1.8 g, 6.01 mmol) in toluene (30.0 ml), was added 2-oxocyclopentanecarbonitrile (984 mg, 9.02 mmol) and 4- methylbenzenesulfonic acid hydrate ( 114 mg, 0.60 mmol) . The reaction was refluxed for 3 hours using a dean-stark and then cooled to room temperature. Saturated aqueous NaHC03 and ethyl acetate were added, the organic layer was separated, washed with brine, dried over MgS04, filtered and concentrated under reduced pressure. Purification by silica gel chromatography provided intermediate 15-f as beige solid . MS (m/z) M + H= 391.5
Statistics shows that 2941-29-9 is playing an increasingly important role. we look forward to future research findings about Cyclopentanone-2-carbonitrile.
Reference:
Patent; PHARMASCIENCE INC.; LAURENT, Alain; ROSE, Yannick; MORRIS, Stephen; JAQUITH, James; WO2012/135937; (2012); A1;,
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