Electric Literature of 939-79-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 939-79-7, name is 4-Methyl-3-nitrobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows.
Step A 2-Methyl-5-(4H-[1,2,4]triazol-3-yl)-phenylamine Hydrogen chloride was bubbled through a solution of 3-nitro-p-tolunitrile (0.49 g, 3 mmol) in 40 mL of EtOH at room temp for 10 min. The solution was stirred at room temp for 60 min, and the solvent was then evaporated under vacuum to dryness to give a white solid. The intermediate so obtained was dissolved in 20 mL of EtOH, neutralized with sodium ethoxide solution, and the resulting precipitate was removed by filtration. To the filtrate at rt. was added formic hydrazide (0.2 g, 3 mmol), stirring of the solution was then continued at room temp for 2 h, then the solvent was evaporated under vacuum. The residue was dissolved in 30 mL of m-xylene and refluxed at 150 C. for 16 h. The solvent was then evaporated under vacuum and the crude product was purified by flash chromatography to afford 0.26 g of nitro intermediate. (Yield: 43%). MS (m/z) calcd for C9H8N4O2 (MH+) 205.2, found, 205.1.
The chemical industry reduces the impact on the environment during synthesis 4-Methyl-3-nitrobenzonitrile. I believe this compound will play a more active role in future production and life.
Reference:
Patent; Leftheris, Katerina; Wrobleski, Stephen T.; Dyckman, Alaric J.; US2005/43306; (2005); A1;,
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