Adding a certain compound to certain chemical reactions, such as: 455-18-5, name is 4-(Trifluoromethyl)benzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 455-18-5, Safety of 4-(Trifluoromethyl)benzonitrile
-Trifluoromethyl-thiobenzamide A solution of oc, a, [A-TRIFLUORO-P-TOLUNITRILE] (603.5 g, 3.53 mol) in dry DMF (2 L) under N2 was heated at [70C] and the Thioacetamide (505 g, 1.9 eq. ) was added. The reaction mixture was treated with HCI gas before 15 minutes and was stirred at [95C] for 6 hours. This treatment was operated 3 times and the mixture was stirred at rt for 24 hours. After cooling at [0C,] water was added and the residue was extracted with diethyl ether (4*1 L). The organic layer was washed with water (3*1 L), dried over [NA2SO4] and then evaporated off. The brownish powder was washed with pentane (3 L) to give the title compound (530.3 g, 2.59 mol) as brown solid in a 73% yield. GC/MS: [M+ C8H6F3NS] 205
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-(Trifluoromethyl)benzonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2004/785; (2003); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts