Related Products of 19472-74-3, A common heterocyclic compound, 19472-74-3, name is 2-Bromophenylacetonitrile, molecular formula is C8H6BrN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
2-(2-bromophenyl)acetonitrile (5.00 g, 25.5 mmol), 4-chlorophenylboronic acid (4.30 g, 27.5 mmol), and tetrakis(triphenylphosphine)palladium(0) (0.48 g 0.42 mmol) were mixed with toluene (57 ml) in a 250 ml 3-necked flask. A reflux condenser was attached and the flask was purged with nitrogen. Aqueous solution of Na2CO3 (2M, 29 ml, 58 mmol) was added by syringe, and the atmosphere was evacuated and replaced with nitrogen. The reaction mixture was heated at reflux overnight, and then allowed to cool at ambient temperature. The mixture was partitioned between saturated aq. NH4Cl and EtOAc (200 ml each). The organic phase was separated, dried (MgSO4), filtered through diatomaceous earth and the filtrate was evaporated under reduced pressure. The residue was purified by column chromatography (ISCO, 120 g silica gel column, 0?20% EtOAc/hexanes) to give the tile compound (5.44 g, yield: 94%). 1H NMR (400 MHz, DMSO-d6) delta ppm 3.91 (s, 2H), 7.26-7.33 (m, 1H), 7.36-7.49 (m, 4H), 7.50-7.59 (m, 3H). LCMS: (ESI) m/z 228 [M+H]+.
The synthetic route of 19472-74-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ASTRAZENECA AB; US2012/35134; (2012); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts