Continuously updated synthesis method about 2-Methylenepentanedinitrile

Statistics shows that 2-Methylenepentanedinitrile is playing an increasingly important role. we look forward to future research findings about 1572-52-7.

Related Products of 1572-52-7, These common heterocyclic compound, 1572-52-7, name is 2-Methylenepentanedinitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Reference example 14 3-(3,4-Dimethylphenylthio)-2-(2-methoxycarbonylethyl)propionic acid A mixture of 3,4-dimethylbenzenethiol (0.59 ml), 2-methyleneglutaronitrile (0.48 ml), ethanol (10 ml), and triton B (40% ethanol solution, 5 drops) was refluxed for 5 hours. After the reaction mixture was concentrated in vacuo, the resulting residue was dissolved in chloroform, washed with water, and dried over MgSO4. The solvent was evaporated at reduced pressure, and the residue was purified by flash column chromatography on silica eluding with benzene/ethyl acetate (7:1) to give 1.18 g of 2-(3,4-dimethylphenylthiomethyl)glutaronitrile as oil. IR (neat): nuCN2230 cmmin1 NMR (CDCl3)

Statistics shows that 2-Methylenepentanedinitrile is playing an increasingly important role. we look forward to future research findings about 1572-52-7.

Reference:
Patent; Kissei Pharmaceutical Co., Ltd.; EP508004; (1992); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts