Application of 139152-08-2, The chemical industry reduces the impact on the environment during synthesis 139152-08-2, name is 4,5-Dichlorophthalonitrile, I believe this compound will play a more active role in future production and life.
Compound 1 (2 g, 4.04 mmol), 4,5-dichloro-1,2-dicyanobenzene(1.6 g, 8.16 mmol) and 20 mL dry DMF were stirred under nitrogenatmosphere for 15 min at 25 C and dry K2CO3 (1.41 g, 10.1 mmol)was added portion-wise for 2 h. The reaction mixture was stirredunder nitrogen atmosphere at 70 C for about 3 days. Then, it wasemptied into ice-water and filtrated. The light brown product wasrecrystallized from ethanol. The raw product was refined by columnchromatography with silica gel, using chloroform/ethanol(98:2). Yield: 1.35 g (54%). m.p.:181-190 C. Anal. calcd. forC36H30O6SN2: C, 69.89; H, 4.89; N, 4.53%. Found: C, 69.93; H, 4.83;N, 4.82%. IR, nmax/cm1 : 3097 (Ar-H), 2920-2869 (Aliph., C-H), 2234(C^N), 1274 (Ar-O-C), 1129-1017 (-OCH2), 826.1H NMR (CDCl3),(delta:ppm): 7.72 (m, 4H, ArH), 7.46 (ddd, 4H, ArH), 7.15 (d, 2H, ArH),7.01 (d, 2H, ArH), 6.84 (d, 2H, ArH), 3.98 (d, 4H, O-CH2), 3.52 (m, 4H,O-CH2), 3.27 (d, 4H, O-CH2), 3.05 (m, 4H, O-CH2). 13C NMR(CDCl3), (delta:ppm): 155.89, 135.43, 129.48, 128.05, 125.92, 124.49,120.59, 118.85, 115.32(C^N), 112.55, 108.61, 72.28, 68.71, 61.32.MS(FAB) (m/z): 615 [M 3].
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4,5-Dichlorophthalonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Arucu, Sevinc; Sa?lam, Meltem Betuel; Oezkaya, Ali R?za; Journal of Molecular Structure; vol. 1198; (2019);,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts