Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 19472-74-3, name is 2-Bromophenylacetonitrile, A new synthetic method of this compound is introduced below., Recommanded Product: 19472-74-3
To a solution of compound 5a (500 mg, 2.12 mmol) and 2-Bromophenylacetonitrile (538 mg, 2.76 mmol) in TMEDA (3 mL) and H2O (0.1 mL) was added Na2PdCl4 (6.23 mg, 0.02 mmol), CuI (7.62 mg, 0.04mmol) and 2-(Di-tert-butylphosphino)-1-phenylindole (13.5 mg, 0.04mmol). Under Ar, the mixture was warmed to 80 C and stirred for 3 h. After the mixture was cooled to warm temperature, water was added. The resulting solution was extracted with ethyl acetate and washed with water and brine. The organic solution was dried over sodium sulfate, concentrated in vacuo. The residue was purified by silica gel chromatography (petroleum/ethyl acetate 5:1) to give 462 mg of compound 6 (yield: 62%) as a colorless liquid. 1H NMR (400 MHz, CDCl3): delta 7.50 – 7.44 (m, 2H), 7.38 (td, 1H, J = 7.6, 1.3 Hz), 7.30 (t, 1H, J = 7.5 Hz), 7.15 (t, 1H, J = 8.7 Hz), 6.78 – 6.70 (m, 2H), 4.93 (s, 2H), 3.72 (s, 3H), 3.79 (s, 2H), 2.95 – 2.89 (m, 2H), 2.60 (t, 2H, J = 7.6 Hz). MS (EI) m/z: 351 (M+).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Huang, Jing; Guo, Bin; Chu, Wen-Jing; Xie, Xin; Yang, Yu-She; Zhou, Xian-Li; Chinese Chemical Letters; vol. 27; 1; (2016); p. 159 – 162;,
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