Related Products of 2338-75-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2338-75-2, name is 4-(Trifluoromethyl)phenylacetonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
General procedure: Compound 3 (0.85 g, 1.37 mmol) and 2-(p-tolyl)acetonitrile (0.45 g,3.43 mmol) were added into dry ethanol (75 mL), and then CH3ONa(0.19 g, 3.52 mmol) was added quickly. The mixture was refluxed withstirring for 6 h under an atmosphere of nitrogen. After cooling to roomtemperature, the resulting precipitate was collected by filtration, anddried under vacuum. The crude product was purified by column chromatography(silica gel, CH2Cl2/petroleum ether, v/v=3/1), affordinga yellow-green solid (1.03 g).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-(Trifluoromethyl)phenylacetonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Wang, Yonghui; Liu, Jingran; Yuan, Weiliang; Wang, Ying; Zhou, Hongke; Liu, Xingliang; Cao, Jianfang; Zhang, Chao; Dyes and Pigments; vol. 167; (2019); p. 135 – 142;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts