Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 127946-77-4, name is 1-Amino-1-cyclopropanecarbonitrile hydrochloride, A new synthetic method of this compound is introduced below., Safety of 1-Amino-1-cyclopropanecarbonitrile hydrochloride
In a 10 mL round-bottomed flask, example 7G) (35 mg, 89.8 mumol, Eq: 1.00) was combined with DMF (1 mL) to give a light brown solution. HATU (68.3 mg, 180 mumol, Eq: 2.00), 1-aminocyclo-propanecarbonitrile hydrochloride (13.0 mg, 108 mumol, Eq: 1.20) and Hunig’s base (40.6 mg, 54.9 muL, 314 mumol, Eq: 3.50) were added. The reaction mixture was stirred at 22 C. for 20 h. The reaction mixture was poured into saturated aqueous NaHCO3 solution and extracted with DCM (2*). The organic layers were combined, washed with water (3*) and brine (1*). The organic layers were dried over Na2SO4 and concentrated in vacuo. The crude material was purified by flash chromatography (silica gel, 10 g, n-heptane/AcOEt 1/1) and preparative HPLC to yield a light brown powder (11 mg; 27%). m/z=454.2 [M+H]+.
The synthetic route of 127946-77-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; HOFFMANN-LA ROCHE INC.; Anselm, Lilli; Banner, David; Blanc, Jean-Baptiste; Gaufreteau, Delphine; Haap, Wolfgang; Hartmann, Guido; Kuhn, Bernd; Luebbers, Thomas; Peters, Jens-Uwe; Spinnler, Beat; US2013/196965; (2013); A1;,
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