Synthetic Route of 7251-09-4, The chemical industry reduces the impact on the environment during synthesis 7251-09-4, name is 4-Amino-2-methoxybenzonitrile, I believe this compound will play a more active role in future production and life.
Reference Example 8 4-iodo-2-methoxybenzonitrile To a suspension of copper iodide (4.63 g) in acetonitrile (50 mL) was added tert-butyl nitrite (3.61 mL) at room temperature, a solution of 4-amino-2-methoxybenzonitrile (3.00 g) in acetonitrile (30 mL) was added dropwise thereto at 65 C. and, after the completion of the dropwise addition, the mixture was further stirred at 65 C. for 2 hr. The reaction mixture was added to aqueous sodium thiosulfate solution, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography, and the obtained solid was washed with diisopropyl ether to give the title compound as a yellow solid (yield: 2.56 g, 49%). 1H-NMR(CDCl3)delta:3.93(3H,s), 7.24(1H,d,J=8.1 Hz), 7.33(1H,d,J=1.1 Hz), 7.39(1H,dd,J=8.1,1.1 Hz).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Amino-2-methoxybenzonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Takeda Pharmaceutical Company Limited; US2009/42967; (2009); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts