127946-77-4, Name is 1-Amino-1-cyclopropanecarbonitrile hydrochloride, 127946-77-4, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.
A mixture of example 9a) (850 mg, 2.74 mmol, Eq: 1.00), 1-aminocyclopropane- carbonitrile hydrochloride (422 mg, 3.56 mmol, Eq: 1.30), sodium 2-ethylhexanoate (705 mg, 4.24 mmol, Eq: 1.55) in water (3 ml) and THF (2.00 ml) was stuffed at 55 C for 18 h. To the reaction mixture were added hydrochloric acid (189 mg, 157 tl, 1.91 mmol, Eq:0.70) and sodium chloride (1.36 g, 1.36 ml, 23.3 mmol, Eq: 8.50). The mixture was stuffed for 15 mm, then poured into AcOEt (25 ml) and extracted. The aqueous layer was back- extracted with AcOEt (3 x 20 ml). The organic layers were dried over Na2SO4 and concentrated in vacuo. The crude material was purified by flash chromatography (silica gel, 40 g, 0% to 90% EtOAc in heptane) to yield the title compound as white foam (560 mg;52 %). mlz = 393.0 [M+Hf?.
Statistics shows that 1-Amino-1-cyclopropanecarbonitrile hydrochloride is playing an increasingly important role. we look forward to future research findings about 127946-77-4.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; ANSELM, Lilli; BANNER, David; HAAP, Wolfgang; KUHN, Bernd; LUEBBERS, Thomas; PETERS, Jens-Uwe; SPINNLER, Beat; WO2014/29722; (2014); A1;,
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