16532-79-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 16532-79-9, name is 4-Bromophenylacetonitrile, This compound has unique chemical properties. The synthetic route is as follows.
A solution of 4-Bromophenylacetonitrile (10.0 g, 51.0 mmol) in tetrahydrofuran (200 mL) was added slowly to a suspension of sodium hydride (60% in mineral oil, 6.0 g, 153 mmol) in tetrahydrofuran (400 mL) at room temperature over 30 minutes. After complete addition, methyl iodide (7.6 mL, 122 mmol) was added slowly over 30 minutes, maintaining the reaction temperature below 40 C. by occasional immersion into a water bath. The reaction was then stirred overnight at room temperature. The mixture was poured into water (500 mL) and extracted into ethyl acetate (2*300 mL). The combine organic layers were washed with brine (2*300 mL), dried over magnesium sulfate, filtered and concentrated. Crude purified on silica gel eluding with 2% ethyl acetate in hexanes) to give 2-(4-bromophenyl)-2-methylpropanenitrile (11 g, 96%) as a yellow oil. 1H NMR (300 MHz, CDCl3): delta ppm 1.70 (s, 6H), 7.35 (dd, 2H), 7.53 (dd, 2H).
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Reference:
Patent; pfizer Inc; US2010/197591; (2010); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts