In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 67515-59-7 as follows. SDS of cas: 67515-59-7
In 10 ml of anhydrous DMF (dimethylformamide)The product was obtained by reverse synthesis of 4-fluoro-3- (trifluoromethyl) benzonitrile (1 g; 5.2 mmol) and carbazole (0.88 g; 5.2 mmol) in the presence of potassium carbonate (1.44 g; 10.4 mmol)The reaction mixture was stirred for 20 hours and heated to 80 C.The target material was purified by recrystallisation in diethyl ether / hexanes mixture in a yield of 47% (0.8 g).
According to the analysis of related databases, 67515-59-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Dresden Industry Technology University; La Munasi·ligaidi; Lai Yinhade·xiaoerci; Ao Lafu·caika; Sai Basidian·laineike; Ka Er·laiao; Xi Meng·huofuman; Ma Ding·aobolundeer; (42 pag.)CN107454897; (2017); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts