Application of 13531-48-1, These common heterocyclic compound, 13531-48-1, name is Methyl 3-cyanobenzoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: To a round-bottom flask (25 mL) was added phenylhydrazine hydrochloride 1a (43 mg, 0.3 mmol), benzonitrile 2a (0.3 mL, 3 mmol), t-BuONO (53 muL, 0.45 mmol), I2 (38 mg, 0.15 mmol), the mixture was well stirred for 6 h at 25 oC (the whole process was closely monitored by TLC). Then the reaction mixture was purified by a flash silica gel column chromatography (eluent: Petroleum ether (PE)/Ethyl acetate (EA) = 10:1) to give N-phenylbenzamide 3a as a white solid (38 mg, 64%).
Statistics shows that Methyl 3-cyanobenzoate is playing an increasingly important role. we look forward to future research findings about 13531-48-1.
Reference:
Article; Zhang, Zhiguo; Li, Xiang; Li, Yinghua; Guo, Yan; Zhao, Xunan; Yan, Yan; Sun, Kai; Zhang, Guisheng; Tetrahedron; vol. 75; 26; (2019); p. 3628 – 3635;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts