2042-37-7, name is 2-Bromobenzonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Computed Properties of C7H4BrN
Example 2 2M Sodium carbonate solution (200 ml) was added to a stirred mixture of 4-methylphenylboronic acid (30 g), 2-bromobenzonitrile (36.4 g), palladium (II) chloride (0.4 g), methanol (200 ml) and toluene (200 ml) at 5C. The temperature rose to approximately 20C and a solid precipitated. The reaction mixture was then heated at reflux for 2 hours. The reaction mixture was allowed to cool and water (100 ml) was added, followed by diatomaceous earth (5 g). The mixture was stirred for 15 minutes, then filtered through diatomaceous earth. The organic phase of the filtrate was separated and washed with 2M sodium carbonate solution and then water. The organic phase was then filtered and the filtrate evaporated. The resultant solid was recrystallized from petroleum ether (b.p. 110-120C) to give 4–methylbiphenyl-2-carbonitrile (in 80% yield) identical to that obtained in Example 1.
The synthetic route of 2042-37-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ZENECA LIMITED; EP470795; (1992); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts