326-62-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 326-62-5 name is 2-(2-Fluorophenyl)acetonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
[0214] To a solution of (2-fluoro-phenyl)-acetonitrile (1.50 g, 11.1 mmol) and EtOAc (4.4 mL, 44.4 mmol) in THF (20 mL) was added NaH (0.90 g, 22.2 mmol). The mixture was stirred at room temperature overnight. Then the reaction mixture was acidified to pH = 6 with HC1 (1 mol/L) and extracted with EtOAc (10 mL x3). The combined organic layer was washed with brine (20 mL), dried with Na2S04 and concentrated to dryness in vacuum. The residue was purified by silica gel column chromatography (PE/EtOAc = 2/1) to afford 2-(2- fluoro-phenyl)-3-oxo-butyronitrile (1.48 g, yield: 76%) as a yellow solid.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-(2-Fluorophenyl)acetonitrile, and friends who are interested can also refer to it.
Reference:
Patent; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; SMITH, Layton H.; PINKERTON, Anthony B.; HERSHBERGER, Paul; MALONEY, Patrick; MCANALLY, Danielle; (167 pag.)WO2019/32720; (2019); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts