21524-39-0, name is 2,3-Difluorobenzonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Formula: C7H3F2N
Potassium nitrate (404 mg, 4.0 mmol) to a solution of 2,3- difluorobenzonitrile (278 mg, 2.0 mmol) in sulfuric acid (2 mL) at 00C. After stirring at 00C for 2 h the reaction was quenched with ice water (5 mL). The mixture was extracted with ethyl acetate (3×10 mL). The organic layer was dried and concentrated to give the crude product which was purified by silica gel (PE : EA = 40 : 1) to give the title compound as a yellow solid. (40 mg, 11%). 1H NMR (400 MHz, CDCl3): delta 8. 25-8.22 (m, IH), 7.69-7.63 (m, IH). LC/MS: m/e = 185 (M+H)+.
The synthetic route of 21524-39-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SEPRACOR INC.; BURDI, Douglas; SPEAR, Kerry, L.; HARDY, Larry, Wendell; WO2010/114971; (2010); A1;,
Nitrile – Wikipedia,
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