Synthetic Route of 1813-33-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1813-33-8, name is 2-Chloro-4-(trifluoromethyl)benzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
General procedure: 2-Chloro-4-(trifluoromethyl)-benzonitrile(1.00 mmol) was dissolved in appropriate alcohol, and DBU(2.00 mmol) was added. The mixture was stirred for 3 h at 80 C.The reaction was quenched with water and extracted with EtOActwice. The combined organic extracts were dried over MgSO4,filtered, and concentrated in vacuo. The residue was purified byflash column chromatography on silica gel using EtOAc/hexane(1:4) eluant condition.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Chloro-4-(trifluoromethyl)benzonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Ann, Jihyae; Jung, Aeran; Kim, Mi-Yeon; Kim, Hyuk-Min; Ryu, Hyungchul; Kim, Sunjoo; Kang, Dong Wook; Hong, Sunhye; Cui, Minghua; Choi, Sun; Blumberg, Peter M.; Frank-Foltyn, Robert; Bahrenberg, Gregor; Stockhausen, Hannelore; Christoph, Thomas; Lee, Jeewoo; Bioorganic and Medicinal Chemistry; vol. 23; 21; (2015); p. 6844 – 6854;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts