16532-79-9, Adding some certain compound to certain chemical reactions, such as: 16532-79-9, name is 4-Bromophenylacetonitrile, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 16532-79-9.
Under nitrogen atmosphere, a mixture of (4-(diphenylamino)phenyl)boronic acid (1.74 g, 6 mmol), 2-(4-bromophenyl)acetonitrile (0.98 g, 5mmol), Pd(PPh3)4 (0.065 g, 0.06 mmol), Na2CO3 (2.0 M, 3.0 mL), and toluene (50 mL)/THF (30 mL) was stirred at 90 C for 24 h. After it was cooled to room temperature, CHCl3 (100 mL) was added to the mixture. The organic portion was separated and washed with brine before dried over anhydrous MgSO4. The solvent was evaporated off, and the solid residues were purified by column chromatography to afford 1.26 g of 2 (green powder) with a yield of 69.9%. FTIR (KBr): upsilon = 2949 cm-1, 2230cm-1, 1595 cm-1, 1523 cm-1, 1490 cm-1, 1080 cm-1 1H NMR (500MHz, CDCl3): delta (ppm) 7.60 (2H, d, J = 8.5 Hz, H in phenyl), 7.47 (2H, d, J = 8.5 Hz, H in phenyl), 7.40 (2H, d, J = 8.0 Hz, H in phenyl), 7.30 (4H, t, J = 7.5 Hz, H in phenyl), 7.16 (6H, d, J = 8.5 Hz, H in phenyl), 7.07 (2H, t, J = 7.5 Hz, H in phenyl), 3.80 (2H, s, H in methylene). 13C NMR(125 MHz, CDCl3): delta (ppm) 147.59, 140.59, 133.89, 129.32, 128.34, 128.25, 127.68, 127.27, 124.56, 123.71, 123.11, 117.82, 23.31. HRMS m/z: Found 361.1695 [M+H]+; molecular formula C26H21N2 requires361.1699 [M+H]+.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 16532-79-9.
Reference:
Article; Cao, Feng; Li, Chengjian; Lv, Chunyan; Ouyang, Mi; Pan, Guoxiang; Sun, Jingwei; Yang, Shengchen; Zhang, Cheng; Zhang, Yujian; Zhuo, Chaozheng; Dyes and Pigments; vol. 180; (2020);,
Nitrile – Wikipedia,
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