In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 939-80-0 as follows. 939-80-0
[00283] 4-(2,5-Dichlorophenoxy)-3-nitrobenzonitrile 34. 2,5-Dichlorophenol (17.86 g,109.54 mmol) and 4-chloro-3-nitrobenzonitrile (10.00 g, 54.77 mmol) were combined with K2CO3 (37.85 g, 273.85 mmol) in THF (300 niL). The reaction mixture was refluxed for 48 hrs and then the solid was filtered over a bed of Celite. After rinsing the residue with copious amounts of DCM, the filtrate was concentrated to produce a yellow solid. The solid was triturated with minimal DCM and collected via vacuum filtration to yield compound 34 (13.84 g, 81.7% yield, 100.0% pure). 1H NMR (500 MHz, DMSO-4): delta 8.73 (s, IH), 8.12 (dd, J1 = 9 Hz, J2 = 2 Hz, IH), 7.73 (d, / = 9 Hz, IH), 7.65 (d, / = 2 Hz, IH), 7.48 (dd, J1 = 9 Hz, J2 = 2 Hz, IH), 7.21 (d, / = 9 Hz, IH).
According to the analysis of related databases, 939-80-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; AXIKIN PHARMACEUTICALS, INC.; LY, Tai, Wei; TRAN, Marie Chantal, Siu-ying; BAAUM, Erik, Dean; WO2010/123956; (2010); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts