Adding a certain compound to certain chemical reactions, such as: 362527-61-5, name is Ethyl 3-bromo-4-cyanobenzoate, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 362527-61-5, name: Ethyl 3-bromo-4-cyanobenzoate
STEP 1 : A mixture of ethyl 3-bromo-4-cyanobenzoate (500 mg, 2.08 mmol), 2-methylpropan-l -amine (250 muL, 4.16 mmol), Pd2(dba)3 (96 mg, 5 mol%), Xantphos (120 mg, 10 mol%) and potassium phosphate (959 mg, 4.16 mmol) in dioxane (10 mL) was stirred for overnight at 95 0C. After cooling to room temperature the mixture was diluted with water and extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate, filtered, and concentrated followed by column chromatography (10 % ethyl acetate in hexanes) to give ethyl 4- cyano-3-[(2-methylpropylamino)]benzoate (393 mg, 76.7 %) as a yellow solid. ‘ MS(EI) for C14H18N2O2: 247.1 (MH+).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 3-bromo-4-cyanobenzoate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; EXELIXIS, INC.; WO2009/55077; (2009); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts