17626-40-3, name is 3,4-Diaminobenzonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 17626-40-3
A solution of 1 (557.5 mg, 2.5 mmol), 3, 4-diaminobenzonitrile (332.5 mg, 2.5 mmol), and benzoquinone (270.2 mg, 2.5 mmol) in ethanol (40 mL) was allowed to reflux under nitrogen for overnight. The reaction mixture was distilled off under reduced pressure. The residue was triturated with ether and filtered off to afford 2 in 90%, mp >340 C.’H NMR (DMSO-d6) ; J 7.20 (d, J = 8.4 Hz, 1 H), 7.68 (d, J = 8.4 Hz, 1 H), 7.86-7. 98 (m, 6H), 8.28 (s, 1 H), 8.57 (s, 1H), 12.80 (brs, 1H), 13.65 (brs, 1H). 13C NMR ; No. 158. 4, 153. 9,143. 5,132. 9, 131.0, 129.3, 126.7, 125.7, 119.7, 118.9, 118.1, 112.8, 109.4, 104.5. MS (m/z, rel. int. ); 336 (M+, 100), 307 (25), 280 (5), 164 (10). High resolution calcd. for C21H12N4O ms 336. 10111. Observed 336.10189. Anal. (C21H12N4O-0.25H2O) C, H, N.
Statistics shows that 17626-40-3 is playing an increasingly important role. we look forward to future research findings about 3,4-Diaminobenzonitrile.
Reference:
Patent; UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL; GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.; WO2005/40132; (2005); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts