Application of 34662-24-3, A common heterocyclic compound, 34662-24-3, name is 2-Chloro-3-nitrobenzonitrile, molecular formula is C7H3ClN2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step c) intermediate 11Synthesis of 2-[(2-hydroxyethyl)amino]-3-nitrobenzonitrile2-chloro-3-nitrobenzonitrile (74g, 0.408 mol) is mixed with ethanol (370 ml) and ethanolamine (57 ml). The mixture is stirred for 16 hrs at room temperature. To complete the reaction, the mixture is refluxed for 2 hours. After cooling, the mixture is concentrated under vacuum; the product precipitates as a red solid. To eliminate the ethanolamine hydrochloride salt, the suspension is triturated with 500 ml of water and filtrated under vacuum. The solid is washed with ethanol and ether then dried to give the desired product (75g, 89%).IH NMR (300MHz, DMSO-d6) delta ppm 3.55-3.60 (m,2H) 3.69-3.74 (m,2H) 6.75 (dd, 7=7.63, 8.52 Hz, 2H) 7.90 (dd, /=7.63, 1.76 Hz, 2H) 8.27 (dd, /=8.52, 1.76 Hz, IH) 3.35 m, IH)
The synthetic route of 34662-24-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ASTRAZENECA AB; WO2008/18827; (2008); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts