Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 34662-24-3, name is 2-Chloro-3-nitrobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 2-Chloro-3-nitrobenzonitrile
Example 1732- [4-(l-Benzofuran-5-yl)phenyl]-l-{[(3S)-l-(cyclopropylcarbonyl)-3- pyrrolidinyl] methyl}- lH-benzimidazole-7-carbonitrile(a) 2-({[(3S)-l-(Cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}amino)-3- nitrobenzonitrileA mixture of {[(3S)-l-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}amine (553 mg, 3.29 mmol), 2-chloro-3 -nitrobenzonitrile (500 mg, 2.74 mmol), and DIEA (1.431 mL, 8.22 mmol) were dissolved in 1,4-dioxane (10 mL) in a microwave Vial. The mixture was heated at 150 C for 1 hour. The mixture was evaporated, taken up in DCM and washed with water. The aqueous layer was extracted with DCM and the combined organics evaporated and purified by silica gel column chromatography using a gradient of 0-5% MeOH/DCM to afford the titled compound (800 mg, 2.55 mmol, 93 % yield) as an orange solid. 1H NMR (400 MHz, chloroform-d) delta ppm 0.71-0.88 (m, 2 H) 0.94-1.12 (m, 2 H) 1.59-1.69 (m, 1 H) 1.69-2.00 (m, 1 H) 2.11-2.41 (m, 1 H) 2.55-2.92 (m, 0 H) 3.16-4.11 (m, 6 H) 6.80 (ddd, J=10.04, 8.40, 7.58 Hz, 1 H) 7.79 (ddd, J=9.35, 7.71, 1.39 Hz, 1 H) 8.27- 8.49 (m, 1 H) 8.53-8.80 (m, 1 H).
According to the analysis of related databases, 34662-24-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; GLAXOSMITHKLINE LLC; HALLMAN, Jason; LAUDEMAN, Christopher; LIU, Ronggang; MILLER, Aaron; MOORE, Michael, Lee; DOCK, Steven; MUSSO, David; PARRISH, Cynthia; WO2011/56635; (2011); A1;,
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